HIPEC

Heated Intraperitoneal Chemotherapy is a novel procedure in the management of peritoneal carcinomatosis including ovarian cancers. In this procedure, chemotherapeutic agents are heated to a temperature of 41-43 degree Celcius and then uniformaly distributed in the abdominal cavity for 90 minutes after the cytoreductive surgery for ovarian cancer is done. Combined surgery and chemotherapy by this route is an extensive procedure and referred to as MOAS( Mother of All Surgeries). ⦁ Term HIPEC coined by the group from the Netherlands Cancer Institute and is used world over in the management of peritoneal carcinomas.

Hyperthermia

• Hyperthermia It self exhibits a selective cell-killing effect to malignant cells potentiates the cytotoxic effect of chemotherapy agents, enhances the tissue penetration of the administered drug.
• The intraperitoneal route, when properly used, will allow uniform distribution by surgeon/ positional changes high concentration of anticancer therapy at the site of the malignancy When disease load is minimal
• Isolated tumor nodules are removed using electroevaporation (viable tumor cells at margin)
• Electroevaporation/ electrosurgery
• Less blood loss, less dissemination of tumor cells. High energy likely to kill tumor cells at resection margin